The film opens with a narrated disclaimer over footage of an opening coffin. The narrator explains that the film's climax is so terrifying that it may kill the viewer, and reassures the audience that if they die of fright while watching the film, they will receive a free burial service, and it closes on the casket which has a card inside reading Reserved for You.[1]　　Newlyweds Jenni (Peggy Webber) and Eric (John Hudson) move into Eric's palatial country home. Jenni is Eric's second wife; his first wife Marion died when she accidentally slipped and hit her head on the edge of a decorative pond on the estate. At the home they meet Eric's friends, the Reverend Snow (Russ Conway) and his wife (Toni Johnson), as well as Mickey (Alex Nicol), the developmentally disabled gardener. Eric privately mentions to the Snows that Jenni spent time in an asylum following the sudden death of both her parents, and Mrs. Snow reveals that Jenni is very wealthy.　　Jenni is disturbed both by Mickey's belief that Marion's ghost wanders the estate and by Marion's self-portrait inside the house, which Jenni believes resembles her mother. When she begins to hear unexplained screaming noises and see skulls around her house, she believes that Marion is haunting her. Though Eric speculates to Jenni that Mickey, who was a childhood friend of Marion and thus dislikes Jenni, may be behind the trickery, Jenni worries that she is going insane. Eric then suggests to remove Marion's self-portrait from the home. Eric and Jenni take the painting outside and burn it. While they clean up the remains of the painting, a skull emerges from the ashes. While Jenni panics at the sight of the skull, Eric denies that the skull is there. Jenni faints and Eric withdraws the skull and hides it, revealing that he was responsible for the trickery all along in an effort to get hold of her wealth.　　Believing she has finally lost her sanity, Jenni resolves to be committed. She tells Eric that the entire property will be meticulously searched for the skull as a last resort. Before Eric can retrieve it, Mickey secretly steals the skull and brings it to the Reverend, revealing Eric's plans. That night, Eric prepares to murder Jenni and stage it as a suicide. Jenni sees Marion's ghost in Mickey's greenhouse and flees back to the house. When she enters, Eric begins throttling her. The ghost then appears and chases Eric outside and about the property; it finally corners and attacks him, drowning him in the decorative pond.　　After Jenni regains consciousness, the Snows arrive. Mrs. Snow comforts a hysterical Jenni and the Reverend discovers Eric's body in the pond. Some undisclosed time later, Jenni and the Snows depart from the house. Reverend Snow declares whether or not Marion's death was an accident will remain a mystery.

124.192.134.*：我的外婆是鬼师，专门帮人问鬼求神做法事的。她说真正的鬼是不会主动招人的！我给她看尖叫的头骨，她说拍得不错，最好是在白天拍，说明约翰·还是很聪明的！

171.88.167.*：还记得第一遍看的时候，大中午看完吓得我大白天不敢去上学，简直童年阴影[笑哭]。

103.78.152.*：1958年真是恐怖黄金年代，好片层出不穷！

36.26.33.*：有人是因为喜欢约翰·赫德森才看的这部的吗？

116.7.161.*：为什么国语声音好小，你们声音大吗？

101.74.209.*：突然觉得，太平间看守的小伙子看女尸特别漂亮，就脱裤子搞事，然后女尸就复活了。后来查原因，大概就是小伙子的刺激导致假死状态的女子复活了。最终结局是女方家没起诉小伙子。所以说故事里老王家女儿为什么复活，感觉其中有点事儿。

123.119.20.*：特别喜欢看恐怖，还有其他恐怖推荐吗？

166.10.165.*：找了好久尖叫的头骨，终于找了，想看个国语版太不容易了！

114.238.99.*：尖叫的头骨是1958最好看的恐怖。

112.24.228.*：尖叫的头骨好看吗？我还没看

222.175.19.*：为什么尖叫的头骨下载总是在99%卡住了！！！

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